Low-Density Lipoprotein (LDL)-Antioxidant Biflavonoids from Garcinia madruno

Molecules

Edison Osorio¹  Julián Londoño¹ 

[1] Grupo de Investigación en Sustancias Bioactivas, Facultad de Química Farmacéutica, Universidad de Antioquia, Carrera 53 n 61-30., A.A. 1226, Medellín, Colombia; E-Mail:

关键词: Garcinia madruno;    Clusiaceae;    bioflavonoids;    LDL-antioxidant;   

DOI  :  10.3390/molecules18056092

来源: mdpi

【 摘 要 】

Six biflavonoids were isolated from G. madruno, one of which, 7''-O-(6''''-acetyl)-glucoside of morelloflavone, is a new compound identified on the basis of 1D, 2D NMR (HMQC and HMBC) spectroscopic methods and chemical evidence. The antioxidant activity of the biflavonoids against low-density lipoprotein (LDL) peroxidation induced with Cu²⁺, was studied by means of a TBARS assay. The antioxidant potential of a biflavonoid fraction (BF) was also evaluated and correlated with its biflavonoid content. The flavanone-(3→8'')-flavone biflavonoids displayed antioxidant activity, particularly morelloflavone, which was significantly more potent than quercetin, with a CE₅₀ of 12.36 μg/mL. Lipid peroxidation, was also significantly reduced in the presence of the BF (EC₅₀ = 11.85 μg/mL). These results suggest that the BF is an excellent antioxidant.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.