The Dynamics of HCF-1 Modulation of Herpes Simplex Virus Chromatin during Initiation of Infection

Viruses

Jodi L. Vogel¹ 

[1] National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bld. 33, 33 North Drive, Bethesda, MD 20892, USA; E-Mail

关键词: herpes simplex virus;    chromatin;    HCF-1;    Setd1A;    latency;    histone demethylase;   

DOI  :  10.3390/v5051272

来源: mdpi

【 摘 要 】

Successful infection of herpes simplex virus is dependent upon chromatin modulation by the cellular coactivator host cell factor-1 (HCF-1). This review focuses on the multiple chromatin modulation components associated with HCF-1 and the chromatin-related dynamics mediated by this coactivator that lead to the initiation of herpes simplex virus (HSV) immediate early gene expression.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.