Epigenetic Control of Cytomegalovirus Latency and Reactivation

Viruses

Xue-feng Liu¹  Xueqiong Wang¹  Shixian Yan¹  Zheng Zhang¹  Michael Abecassis¹ 

[1] Department of Surgery, Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Ave., Chicago, IL 60611, USA; E-Mails:

关键词: cytomegalovirus;    latency;    reactivation;    epigenetics;    chromatin;    intrinsic immunity;    transplantation;   

DOI  :  10.3390/v5051325

来源: mdpi

【 摘 要 】

Cytomegalovirus (CMV) gene expression is repressed in latency due to heterochromatinization of viral genomes. In murine CMV (MCMV) latently infected mice, viral genomes are bound to histones with heterochromatic modifications, to enzymes that mediate these modifications, and to adaptor proteins that may recruit co-repressor complexes. Kinetic analyses of repressor binding show that these repressors are recruited at the earliest time of infection, suggesting that latency may be the default state. Kidney transplantation leads to epigenetic reprogramming of latent viral chromatin and reactivation of immediate early gene expression. Inflammatory signaling pathways, which activate transcription factors that regulate the major immediate early promoter (MIEP), likely mediate the switch in viral chromatin.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.