The Chromatin Landscape of Kaposi’s Sarcoma-Associated Herpesvirus

Viruses

Zsolt Toth¹  Kevin Brulois² 

[1] Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Harlyne J. Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, CA 90033, USA;

关键词: Kaposi’s sarcoma-associated herpesvirus;    KSHV;    KS;    viral chromatin;    polycomb;    EZH2;    minichromosome;    histone modifications;    MLL/Set1;    JMJD2A;   

DOI  :  10.3390/v5051346

来源: mdpi

【 摘 要 】

Kaposi’s sarcoma-associated herpesvirus is an oncogenic γ-herpesvirus that causes latent infection in humans. In cells, the viral genome adopts a highly organized chromatin structure, which is controlled by a wide variety of cellular and viral chromatin regulatory factors. In the past few years, interrogation of the chromatinized KSHV genome by whole genome-analyzing tools revealed that the complex chromatin landscape spanning the viral genome in infected cells has important regulatory roles during the viral life cycle. This review summarizes the most recent findings regarding the role of histone modifications, histone modifying enzymes, DNA methylation, microRNAs, non-coding RNAs and the nuclear organization of the KSHV epigenome in the regulation of latent and lytic viral gene expression programs as well as their connection to KSHV-associated pathogenesis.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.