Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum

Marine Drugs

Hui-Yu Fang²  Chi-Hsin Hsu²  Chih-Hua Chao²  Zhi-Hong Wen²  Yang-Chang Wu¹  Chang-Feng Dai³ 

[1] School of Pharmacy, China Medical University, Taichung 40402, Taiwan; E-Mail:;Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan; E-Mails:;Institute of Oceanography, National Taiwan University, Taipei 10617, Taiwan; E-Mail:

关键词: soft coral;    Scleronephthya gracillimum;    cytotoxicity activity;    anti-inflammatory activity;   

DOI  :  10.3390/md11061853

来源: mdpi

【 摘 要 】

Five new pregnane-type steroids, sclerosteroids J–N (1–5), and a diterpenoid with a new chemotype 3-methyl-5-(10′-acetoxy-2′,6′,10′-trimethylundecyl)-2-penten-5-olide (6), have been isolated from a soft coral Scleronephthya gracillimum. The structures of the metabolites were determined by extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against HepG2, A549, and MDA-MB-231 cancer cell lines. Furthermore, steroids 2 and 4 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein, and 1, 2, 4 and 5 could effectively reduce the accumulation of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.