Molecules | |
Dimeric Labdane Diterpenes: Synthesis and Antiproliferative Effects | |
Mariano Walter Pertino1  Cristina Theoduloz2  Marco Basts1  | |
[1] Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile;Facultad de Ciencias de la Salud, Universidad de Talca, Talca, Chile | |
关键词: labdane diterpene dimers; click chemistry; semisynthesis; antiproliferative activity; | |
DOI : 10.3390/molecules18055936 | |
来源: mdpi | |
【 摘 要 】
Several diterpenes with the labdane skeleton show biological activity, including antiproliferative effects. Most of the research work on bioactive labdanes has been carried out on naturally occurring diterpenes and semisynthetic derivatives, but much less is known on the effects of diterpene dimers. The aim of the present work was to synthesize dimeric diterpenes from the labdane imbricatolic acid using esters, ethers and the triazole ring as linkers. Some 18 new derivatives were prepared and the compounds were evaluated for antiproliferative activity on human normal fibroblasts (MRC-5) and the following human tumor cell lines: AGS, SK-MES-1, J82 and HL-60. The diethers
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190035985ZK.pdf | 240KB | download |