Current Therapeutic Strategies and Novel Approaches in Osteosarcoma

Cancers

Kosei Ando²  Marie-Françoise Heymann²  Verena Stresing²  Kanji Mori¹  Françoise Rຝini² 

[1] Department of Orthopaedic Surgery, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Shiga 520-2192, Japan; E-Mail:;INSERM, UMR 957, 1 Rue Gaston Veil, 44035 Nantes, France; E-Mails:

关键词: osteosarcoma;    chemotherapy;    surgery;    radiotherapy;    multidisciplinary treatment;    emerging drugs;   

DOI  :  10.3390/cancers5020591

来源: mdpi

【 摘 要 】

Osteosarcoma is the most frequent malignant primary bone tumor and a main cause of cancer-related death in children and adolescents. Although long-term survival in localized osteosarcoma has improved to about 60% during the 1960s and 1970s, long-term survival in both localized and metastatic osteosarcoma has stagnated in the past several decades. Thus, current conventional therapy consists of multi-agent chemotherapy, surgery and radiation, which is not fully adequate for osteosarcoma treatment. Innovative drugs and approaches are needed to further improve outcome in osteosarcoma patients. This review describes the current management of osteosarcoma as well as potential new therapies.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.