Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome

Nutrients

Gerald E. Lobley²  Grietje Holtrop¹  David M. Bremner²  A. Graham Calder²  Eric Milne² 

[1]Biomathematics and Statistics Scotland, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, AB21 9SB, UK

[2] E-Mail:

[3]Obesity and Metabolic Health Division, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, AB21 9SB, UK

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关键词: insulin sensitivity;    stable isotope kinetics;    non-starch polysaccharides;    resistant starch;    weight loss;    Minimal Models;    metabolic syndrome;   

DOI  :  10.3390/nu5062144

来源: mdpi

【 摘 要 】

This study investigated if additional non-starch polysaccharide (NSP) or resistant starch (RS), above that currently recommended, leads to better improvement in insulin sensitivity (IS) than observed with modest weight loss (WL). Obese male volunteers (n = 14) were given an energy-maintenance (M) diet containing 27 g NSP and 5 g RS daily for one week. They then received, in a cross-over design, energy-maintenance intakes of either an NSP-enriched diet (42 g NSP, 2.5 g RS) or an RS-enriched diet (16 g NSP, 25 g RS), each for three weeks. Finally, a high protein (30% calories) WL diet was provided at 8 MJ/day for three weeks. During each dietary intervention, endogenous glucose production (EGP) and IS were assessed. Fasting glycaemia was unaltered by diet, but plasma insulin and C-peptide both decreased with the WL diet (p < 0.001), as did EGP (−11%, p = 0.006). Homeostatis model assessment of insulin resistance improved following both WL (p < 0.001) and RS (p < 0.05) diets. Peripheral tissue IS improved only with WL (57%–83%, p < 0.005). Inclusion of additional RS or NSP above amounts currently recommended resulted in little or no improvement in glycaemic control, whereas moderate WL (approximately 3 kg fat) improved IS.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.