Systems Biology: The Role of Engineering in the Reverse Engineering of Biological Signaling

Cells

关键词: control engineering;    information theory;    signal processing;    statistical inference;    homeostasis;   

DOI  :  10.3390/cells2020393

来源: mdpi

【 摘 要 】

One of the principle tasks of systems biology has been the reverse engineering of signaling networks. Because of the striking similarities to engineering systems, a number of analysis and design tools from engineering disciplines have been used in this process. This review looks at several examples including the analysis of homeostasis using control theory, the attenuation of noise using signal processing, statistical inference and the use of information theory to understand both binary decision systems and the response of eukaryotic chemotactic cells.

【 授权许可】

CC BY   
© 2013 by the author; licensee MDPI, Basel, Switzerland.