89Zr, a Radiometal Nuclide with High Potential for Molecular Imaging with PET: Chemistry, Applications and Remaining Challenges

Molecules

Gabriel Fischer³  Uwe Seibold³  Ralf Schirrmacher¹  Björn Wängler² 

[1] McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada; E-Mail:;Molecular Imaging and Radiochemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University, Mannheim 68167, Germany; E-Mail:;Biomedical Chemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University, Mannheim 68167, Germany; E-Mails:

关键词: biomolecules;    Cerenkov luminescence imaging;    desferrioxamine B;    dosimetry;    positron emission tomography (PET);    ⁸⁹Zr;   

DOI  :  10.3390/molecules18066469

来源: mdpi

【 摘 要 】

Molecular imaging—and especially Positron Emission Tomography (PET)—is of increasing importance for the diagnosis of various diseases and thus is experiencing increasing dissemination. Consequently, there is a growing demand for appropriate PET tracers which allow for a specific accumulation in the target structure as well as its visualization and exhibit decay characteristics matching their in vivo pharmacokinetics. To meet this demand, the development of new targeting vectors as well as the use of uncommon radionuclides becomes increasingly important. Uncommon nuclides in this regard enable the utilization of various selectively accumulating bioactive molecules such as peptides, antibodies, their fragments, other proteins and artificial structures for PET imaging in personalized medicine. Among these radionuclides, ⁸⁹Zr (t_1/2 = 3.27 days and mean E_β+ = 0.389 MeV) has attracted increasing attention within the last years due to its favorably long half-life, which enables imaging at late time-points, being especially favorable in case of slowly-accumulating targeting vectors. This review outlines the recent developments in the field of ⁸⁹Zr-labeled bioactive molecules, their potential and application in PET imaging and beyond, as well as remaining challenges.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.