Candidate Biomarkers for Genetic and Clinicopathological Diagnosis of Endometrial Cancer

International Journal of Molecular Sciences

Kouji Banno¹  Yuya Nogami²  Iori Kisu²  Megumi Yanokura²  Kiyoko Umene²  Kenta Masuda²  Yusuke Kobayashi²  Wataru Yamagami²  Nobuyuki Susumu² 

[1] Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinanomachi 35 Shinjuku-ku, Tokyo 160-8582, Japan;

关键词: endometrial cancer;    microsatellite instability;    MSH6;    DNA hypermethylation;    CHFR;    microRNA;    Lynch syndrome;    PTEN;    K-ras;    CA125;   

DOI  :  10.3390/ijms140612123

来源: mdpi

【 摘 要 】

The recent increase in the frequency of endometrial cancer has emphasized the need for accurate diagnosis and improved treatment. The current diagnosis is still based on conventional pathological indicators, such as clinical stage, tumor differentiation, invasion depth and vascular invasion. However, the genetic mechanisms underlying endometrial cancer have gradually been determined, due to developments in molecular biology, leading to the possibility of new methods of diagnosis and treatment planning. New candidate biomarkers for endometrial cancer include those for molecular epigenetic mutations, such as microRNAs. These biomarkers may permit earlier detection of endometrial cancer and prediction of outcomes and are likely to contribute to future personalized therapy for endometrial cancer.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland