Anti-Tumor Effects of Mfn2 in Gastric Cancer

International Journal of Molecular Sciences

Ge-Er Zhang¹  Hai-Long Jin¹  Xian-Ke Lin²  Chao Chen²  Xiao-Sun Liu²  Qing Zhang² 

[1] Department of Gastrointestinal Surgery, the First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, China;

关键词: gastric cancer;    Mfn2;    biomarker;    anti-tumor gene;   

DOI  :  10.3390/ijms140713005

来源: mdpi

【 摘 要 】

Mitofusin-2 (Mfn2) is a mitochondrial outer membrane protein involved in mitochondrial fusion. Its mutation can cause Charcot-Marie-Tooth disease. Recent studies of Mfn2 in cancer research have not included gastric cancer. We confirmed that Mfn2 expression was lower in tumor tissue than in normal gastric mucosal tissue and that it was negatively correlated with tumor size, indicating an anti-tumor role for Mfn2. In vitro experiments showed that Mfn2 overexpression suppressed gastric cancer cell proliferation and colony formation, weakened the invasion and migratory ability of cancer cells by downregulating MMP-2 and MMP-9, halted the cell cycle and induced apoptosis. Western blotting indicated the likely involvement of P21 and PI3K/Akt signaling. Therefore, Mfn2 is a potential anti-tumor gene and a potential therapeutic target for treating gastric cancer. The progress of gastric cancer may be delayed by controlling Mfn2 expression.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland