Alterations of 5-Hydroxymethylcytosine in Human Cancers

Cancers

Christopher J. Mariani¹  Jozef Madzo¹  Erika L. Moen¹  Ali Yesilkanal¹ 

[1] Section of Hematology/Oncology, Department of Medicine, The University of Chicago, 5841 S. Maryland Ave., MC 2115, Chicago, IL 60637, USA; E-Mails:

关键词: 5-hydroxymethylcytosine;    5-methylcytosine;    cancer;    DNA methylation;    epigenetics;    ten-eleven translocation;    TET;   

DOI  :  10.3390/cancers5030786

来源: mdpi

【 摘 要 】

Prior to 2009, 5-methylcytosine (5-mC) was thought to be the only biologically significant cytosine modification in mammalian DNA. With the discovery of the TET enzymes, which convert 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), however, intense interest has emerged in determining the biological function of 5-hmC. Here, we review the techniques used to study 5-hmC and evidence that alterations to 5-hmC physiology play a functional role in the molecular pathogenesis of human cancers.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.