Monoterpenoid Indole Alkaloids from Alstonia rupestris with Cytotoxic, Anti-Inflammatory and Antifungal Activities

Molecules

Wei Wang¹  Ming-He Cheng² 

[1] Department of Pharmacy, No. 455 Hospital of People’s Liberation Army, Shanghai 200052, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

关键词: Alstonia rupestris;    Apocynaceae;    monoterpenoid indole alkaloids;    cytotoxicity;    anti-inflammatory;    antifungal;   

DOI  :  10.3390/molecules18067309

来源: mdpi

【 摘 要 】

Phytochemical investigation of the 70% EtOH extract of the leaves of Alstonia scholaris afforded seven new monoterpenoid indole alkaloids: scholarisins I-VII (1-7), and three known compounds: (3R,5S,7R,15R,16R,19E)-scholarisine F (8), 3-epi-dihydro- corymine (9), and (E)-16-formyl-5α-methoxystrictamine (10). Structural elucidation of all the compounds was accomplished by spectral methods such as 1D- and 2D-NMR, IR, UV, and HRESIMS. The isolated compounds were tested in vitro for cytotoxicity against seven tumor cell lines, anti-inflammatory activities against Cox-1 and Cox-2, and antifungal potential against five species of fungi. Compounds 1, 6, and 10 exhibited significant cytotoxicities against all the tested tumor cell lines with IC₅₀ values of less than 30 μM and selective inhibition of Cox-2 comparable with the standard drug NS-398 (>90%). Additionally, 1, 2, 3 and 8 showed antifungal activity against two fungal strains (G. pulicaris and C. nicotianae).

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.