Analytical Study for the Charge-Transfer Complexes of Rosuvastatin Calcium with π-Acceptors

Molecules

Nourah Z. Alzoman¹  Maha A. Sultan¹  Hadir M. Maher¹  Mona M. Alshehri¹  Tanveer A. Wani¹ 

[1] Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; E-Mails:

关键词: atherosclerosis;    cholesterol;    rosuvastatin calcium;    charge-transfer complexes;    spectrophotometry;    pharmaceutical analysis;   

DOI  :  10.3390/molecules18077711

来源: mdpi

【 摘 要 】

Studies were carried out to investigate the charge-transfer (CT) reaction of ROS-Ca, as a n-electron donor with various π-acceptors: tetracyanoethylene, p-chloranilic acid, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, 2,3,5,6-tetrabromo-1,4-benzoquinone, 1,3,5-trinitrobenzene, 2,3,5,6-tetrachloro-1,4-benzoquinone, 7,7,8,8-tetracyano-quinodimethane, and 2,4,7-trinitro-9-fluorenone. Different colored CT complexes were obtained. The reaction mechanism and site of interaction were determined by ultraviolet-visible spectrophotometric techniques and computational molecular modeling. The formation of the colored complexes was utilized in the development of simple, rapid and accurate spectrophotometric methods for the determination of ROS-Ca. Under the optimum reaction conditions, linear relationships with good correlation coefficients (0.9984–0.9995) were found between the absorbances and the concentrations of ROS-Ca in the range of 2–200 μg mL⁻¹. The limits of detection ranged from 0.41 to 12.24 μg mL⁻¹. No interference could be observed from the additives commonly present in the tablets or from the drugs that are co-formulated with ROS-Ca in its combined formulations. The methods were successfully applied to the analysis of tablets with good accuracy and precision; the recovery percentages ranged from 99.54–100.46 ± 1.58–1.82%. The results were compared favorably with the reported method. The proposed methods are practical and valuable for routine application in quality control laboratories for determination of ROS-Ca in its bulk form and tablets.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.