Role of Polycomb Proteins in Regulating HSV-1 Latency

Viruses

Zachary Watson¹  Adit Dhummakupt¹  Harald Messer¹  Dane Phelan¹ 

[1] Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Box 100266, Gainesville, FL 32610, USA;

关键词: HSV;    herpes;    PRC;    Polycomb;    heterochromatin;    latency;    reactivation;   

DOI  :  10.3390/v5071740

来源: mdpi

【 摘 要 】

Herpes simplex virus (HSV) establishes a latent infection within sensory neurons of humans. Latency is characterized by the transcriptional repression of lytic genes by the condensation of lytic gene regions into heterochromatin. Recent data suggest that facultative heterochromatin predominates, and that cellular Polycomb proteins are involved in the establishment and maintenance of transcriptional repression during latency. This review summarizes these data and discusses the implication of viral and cellular factors in regulating heterochromatin composition.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.