International Journal of Molecular Sciences | |
Effects of Ospemifene on Drug Metabolism Mediated by Cytochrome P450 Enzymes in Humans |
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Miia Turpeinen2  Jouko Uusitalo1  Terhi Lehtinen3  Marita Kailajärvi3  Olavi Pelkonen2  Jouni Vuorinen6  Pasi Tapanainen4  Camilla Stjernschantz5  Risto Lammintausta5  | |
[1] Technopolis Plc, Oulu 90590, Finland; E-Mail:;Department of Pharmacology and Toxicology, University of Oulu, Oulu 90230, Finland; E-Mail:;Clinical Research Services Turku, Institute of Biomedicine, Turku 20520, Finland; E-Mails:;Vitabalans Ltd., Hämeenlinna 13500, Finland; E-Mail:;Hormos Medical Ltd., Turku 20520, Finland; E-Mails:;Pharma Ltd., Turku 20520, Finland; E-Mail: | |
关键词: bupropion; CYP; omeprazole; selective estrogen receptor modulator; warfarin; | |
DOI : 10.3390/ijms140714064 | |
来源: mdpi | |
【 摘 要 】
The objective of these investigations was to determine the possible effects of the novel selective estrogen receptor modulator, ospemifene, on cytochrome P450 (CYP)-mediated drug metabolism. Ospemifene underwent testing for possible effects on CYP enzyme activity in human liver microsomes and in isolated human hepatocytes. Based on the results obtained
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland
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