Cinnamtannin B-1 Regulates Cell Proliferation of Spinal Cord Astrocytes and Protects the Cell from Oxygen-Glucose-Serum Deprivation/Reoxygenation-Induced Apoptosis

International Journal of Molecular Sciences

Zhiyong Chi¹  Xueling Ma²  Guofeng Cui¹  Mingchao Li¹ 

[1] Department of Orthopaedics, the First Affiliated Hospital of Harbin Medical University, NO.23 Youzheng St., Nangang District, Harbin 150001, China; E-Mails:;Department of Neurology, the Fourth Affiliated Hospital of Harbin Medical University, NO.37 Yiyuan Road, Nangang District, Harbin 150001, China; E-Mail:

关键词: astrocytes;    cinnamtannin B-1;    ischemia/reperfusion;    apoptosis;   

DOI  :  10.3390/ijms140815827

来源: mdpi

【 摘 要 】

Astrocytes are important for protecting neurons in the central nervous system. It has been reported that some antioxidants could protect astrocytes from ischemia/reperfusion-induced dysfunction. Cinnamtannin B-1 is a naturally occurring A-type proanthocyanidin that exhibits anti-oxidant properties. In this study, we investigated the effects of cinnamtannin B-1 on spinal cord astrocytes. Astrocytes were subjected to oxygen-glucose-serum deprivation for eight hours followed by reoxygenation with or without cinnamtannin B-1. We found that cinnamtannin B-1 protected astrocytes from oxygen-glucose-serum deprivation and reoxygenation-induced apoptosis. Concurrently, cinnamtannin B-1 promoted the proliferation of astrocytes whereas the extracellular regulated protein kinase (ERK) inhibitor reversed this effect. The results indicated that cinnamtannin B-1 protects astrocytes from oxygen-glucose-serum deprivation/reoxygenation-induced apoptosis by promoting astrocyte proliferation via an ERK pathway. Therefore, as an anti-oxidant, cinnamtannin B-1 might provide extra benefit for astrocyte protection during ischemia/reperfusion in the central nervous system.

【 授权许可】

CC BY   
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