Fluorescent Magnetic Bioprobes by Surface Modification of Magnetite Nanoparticles

Materials

Paula C. Pinheiro²  Ana L. Daniel-da-Silva²  Daniela S. Tavares²  M. Pilar Calatayud¹  Gerardo F. Goya¹ 

[1] Institute of Nanoscience of Aragón (INA), University of Zaragoza, 50018 Zaragoza, Spain; E-Mails:;Department of Chemistry-CICECO (Centre for Research in Ceramics and Composite Materials), Aveiro Institute of Nanotechnology, University of Aveiro, 3810-193 Aveiro, Portugal; E-Mails:

关键词: magnetic nanoparticles;    fluorescence;    polyelectrolyte;    surface functionalization;   

DOI  :  10.3390/ma6083213

来源: mdpi

【 摘 要 】

Bimodal nanoprobes comprising both magnetic and optical functionalities have been prepared via a sequential two-step process. Firstly, magnetite nanoparticles (MNPs) with well-defined cubic shape and an average dimension of 80 nm were produced by hydrolysis of iron sulfate and were then surface modified with silica shells by using the sol-gel method. The Fe₃O₄@SiO₂ particles were then functionalized with the fluorophore, fluorescein isothiocyanate (FITC), mediated by assembled shells of the cationic polyelectrolyte, polyethyleneimine (PEI). The Fe₃O₄ functionalized particles were then preliminary evaluated as fluorescent and magnetic probes by performing studies in which neuroblast cells have been contacted with these nanomaterials.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.