In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia

Molecules

Nawal M. Al Musayeib¹  Ramzi A. Mothana¹  Ali A. El Gamal¹  Shaza M. Al-Massarani¹ 

[1] Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; E-Mails:

关键词: Kleinia odora;    triterpenes;    antiplasmodial;    antileishmanial;    antitrypanosomal;   

DOI  :  10.3390/molecules18089207

来源: mdpi

【 摘 要 】

Two lupane and four ursane triterpenes, namely epilupeol (1), lupeol acetate (2), ursolic acid (3), brein (4), 3β 11α-dihydroxy urs-12-ene (5) and ursolic acid lactone (6) were isolated from aerial parts of Kleinia odora and identified. Compounds 1 and 3–6 were isolated for the first time from K. odora. The triterpene constituents were investigated for antiprotozoal potential against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. Cytotoxicity was determined against MRC-5 fibroblasts to assess selectivity. The ursane triterpenes were found to be active against more than one type of the tested parasites, with the exception of compound 6. This is also the first report on the occurrence of ursane type triterpenes in the genus Kleinia and their antiprotozoal potential against P. falciparum, L. infantum, T. cruzi, and T. brucei.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.