Immunization against Small Ruminant Lentiviruses

Viruses

Ramsés Reina¹  Damián de Andrés² 

[1] Institute of Agrobiotechnology, CSIC-UPNA-Government of Navarra, Ctra. Mutilva Baja s/n, Navarra 31192, Spain;

关键词: small ruminant lentivirus;    Maedi-Visna;    immunization;   

DOI  :  10.3390/v5081948

来源: mdpi

【 摘 要 】

Multisystemic disease caused by Small Ruminant Lentiviruses (SRLV) in sheep and goats leads to production losses, to the detriment of animal health and welfare. This, together with the lack of treatments, has triggered interest in exploring different strategies of immunization to control the widely spread SRLV infection and, also, to provide a useful model for HIV vaccines. These strategies involve inactivated whole virus, subunit vaccines, DNA encoding viral proteins in the presence or absence of plasmids encoding immunological adjuvants and naturally or artificially attenuated viruses. In this review, we revisit, comprehensively, the immunization strategies against SRLV and analyze this double edged tool individually, as it may contribute to either controlling or enhancing virus replication and/or disease.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.