Anti-Obesity Effect of Artemisia capillaris Extracts in High-Fat Diet-Induced Obese Rats

Molecules

Dong Wook Lim¹  Yun Tai Kim¹  Yu-Jung Jang²  Young-Eon Kim² 

[1] id="af1-molecules-18-09241">Functionality Evaluation Research Group, Korea Food Research Institute, Seongnam 463-746, Kor

关键词: Artemisia capillaris;    scoparone;    hypolipidemic;    anti-obesity;   

DOI  :  10.3390/molecules18089241

来源: mdpi

【 摘 要 】

This study evaluated the anti-obesity effects of Artemisia capillaris extracts in high-fat diet (HFD)-induced obese rats. After six weeks feeding with HFD, Wistar male rats (12-weeks-old) were divided into three groups: HFD-control group and HFD mixed with 0.4% and 0.8% Artemisia capillaris extracts treated groups. After seven weeks of treatments, the body weight gain of the 0.4% and 0.8% A. capillaris extracts treated groups were significantly less than that of the HFD-control group by 11.8% and 15.4%, respectively. Also, A. capillaris extracts treated groups showed significantly lower serum TG, TC and LDL-c levels in a dose-related manner, while causing the reverse effect in serum HDL-c, and exhibited a hepatoprotective effects in vivo, indicated by reduced hepatic lipid contents, and serum ALT and AST levels. These results show that A. capillaris extracts may prevent body weight increases and improve dyslipidemia in HFD-induced obese rats by enhancing their lipid metabolism.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.