Serum Oxidant and Antioxidant Status Following an All-Out 21-km Run in Adolescent Runners Undergoing Professional Training—A One-Year Prospective Trial

International Journal of Molecular Sciences

Tom K. Tong¹  Zhaowei Kong²  Hua Lin⁴  Giuseppe Lippi³  Haifeng Zhang⁵ 

[1] Dr. Stephen Hui Research Centre for Physical Recreation and Wellness, Department of Physical Education, Hong Kong Baptist University, Hong Kong, China; E-Mail:;Faculty of Education, University of Macau, Macao, China; E-Mail:;Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma 43126, Italy; E-Mail:;College of Physical Education, Liaoning Normal University, Dalian 116029, Liaoning, China; E-Mail:;College of Physical Education, Hebei Normal University, Shijiazhuang 050024, Hebei, China; E-Mail:

关键词: adolescent;    oxidative stress;    antioxidant;    endurance exercise;   

DOI  :  10.3390/ijms140715167

来源: mdpi

【 摘 要 】

This study investigated the 1-year longitudinal effect of professional training in adolescent runners on redox balance during intense endurance exercise. Changes in selected serum oxidant and antioxidant status in response to a 21-km running time trial in 10 runners (15.5 ± 1.3 years) undergoing professional training were evaluated twice in 12 months (pre- and post-evaluation). Venous blood samples were collected immediately before and 4-h following the 21-km run for analysis of serum concentrations of thiobarbituric acid-reactive substances (TBARS), xanthine oxidase (XO), catalase (CAT), reduced glutathione (GSH), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC). In pre-evaluation trial, serum TBARS and SOD decreased after the 21-km run (p < 0.05) while XO, GSH, CAT and TAOC were unchanged. In post-evaluation trial, serum TBARS and SOD decreased, whereas XO and CAT increased post-exercise (p < 0.05). Furthermore, pre-exercise serum T-AOC, post-exercise serum XO, CAT, T-AOC (p < 0.05), and GSH (p = 0.057) appeared to be higher than the corresponding pre-evaluation values. The current findings suggest that a professional training regime in adolescent runners is not likely to jeopardize the development of their antioxidant defense. However, uncertainties in the maintenance of redox balance in runners facing increased exercise-induced oxidative stress as a consequence of training-induced enhancement of exercise capacity await further elucidation.

【 授权许可】

CC BY   
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