Antioxidant and Anti-Inflammatory Activities of Barettin

Marine Drugs

Karianne F. Lind¹  Espen Hansen⁴  Bjarne Østerud²  Karl-Erik Eilertsen⁵  Annette Bayer³  Magnus Engqvist³  Kinga Leszczak³  Trond Ø. Jørgensen¹ 

[1] MabCent-SFI, University of Tromsø, Breivika N-9037 Tromsø, Norway; E-Mail:;Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, N-9037 Tromsø, Norway; E-Mail:;Department of Chemistry, University of Tromsø, N-9037 Tromsø, Norway; E-Mails:;Marbio, University of Tromsø, Breivika N-9037 Tromsø, Norway; E-Mails:;Faculty of Biosciences, Fisheries and Economics, University of Tromsø, N-9037 Tromsø, Norway; E-Mail:

关键词: anti-inflammatory;    antioxidant;    barettin;    natural product;   

DOI  :  10.3390/md11072655

来源: mdpi

【 摘 要 】

In this paper, we present novel bioactivity for barettin isolated from the marine sponge Geodia barretti. We found that barettin showed strong antioxidant activity in biochemical assays as well as in a lipid peroxidation cell assay. A de-brominated synthetic analogue of barettin did not show the same activity in the antioxidant cell assay, indicating that bromine is important for cellular activity. Barettin was also able to inhibit the secretion of the inflammatory cytokines IL-1β and TNFα from LPS-stimulated THP-1 cells. This combination of anti-inflammatory and antioxidant activities could indicate that barettin has an atheroprotective effect and may therefore be an interesting product to prevent development of atherosclerosis.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.