Anti-Inflammatory Activity of N-(3-Florophenyl)ethylcaffeamide in Mice

International Journal of Molecular Sciences

Jung-Chun Liao⁵  Jen-Chieh Tsai¹  Wen-Huang Peng⁴  Yung-Jia Chiu⁴  Ping-Jyun Sung²  Minoru Tsuzoki³ 

[1] Department of Health and Nutrition Biotechnology, College of Health Science, Asia University, Taichung 404, Taiwan; E-Mail:;National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; E-Mail:;Nihon Pharmaceutica University, Saitama 362-0806, Japan; E-Mail:;Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan; E-Mail:;School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan; E-Mail:

关键词: anti-inflammatory;    caffeamide;    synthesis;   

DOI  :  10.3390/ijms140815199

来源: mdpi

【 摘 要 】

In this study, we evaluated the anti-inflammatory activity of one synthetic product, N-(3-Florophenyl)ethylcaffeamide (abbrev. FECA), by using animal model of λ-carrageenan-induced paw edema in mice. The anti-inflammatory mechanism of FECA was determined by measuring the levels of cyclooxygenase-2 (COX-2), nitric oxide (NO), tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and malondialdehyde (MDA) in the edema paw tissue, and the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GRd) in the liver. The results showed that FECA reduced the paw edema at three, four and five hours after λ-carrageenan administration. The levels of COX-2, NO, TNF-α, and MDA in the λ-carrageenan-induced edema paws were reduced and the activities of SOD, GPx, and GRd in liver tissues were raised by FECA. These results suggested that FECA possessed anti-inflammatory activities and the anti-inflammatory mechanisms might be related to the decrease of the levels of COX-2, NO, and TNF-α in inflamed tissues and the increase in the MDA level by increasing the activities of SOD, GPx, and GRd.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland