Interaction between Dipolar Lipid Headgroups and Charged Nanoparticles Mediated by Water Dipoles and Ions

International Journal of Molecular Sciences

Aljaž Velikonja²  Poornima Budime Santhosh¹  Ekaterina Gongadze⁵  Mukta Kulkarni⁵  Kristina Eleršič⁴  ᘊrka Perutkova⁵  Veronika Kralj-Iglič³  Nataᘚ Poklar Ulrih¹ 

[1] Department of Food Science and Technology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, Ljubljana SI-1000, Slovenia; E-Mails:;SMARTEH Research and Development of Electronic Controlling and Regulating Systems, Trg tigrovcev 1, Tolmin SI-5220, Slovenia; E-Mail:;Laboratory of Clinical Biophysics, Faculty of Health Studies, University of Ljubljana, Zdravstvena 5, Ljubljana SI-1000, Slovenia; E-Mail:;Jožef Stefan Institute, Jamova 39, Ljubljana SI-1000, Slovenia; E-Mail:;Laboratory of Biophysics, Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, Ljubljana SI-1000, Slovenia; E-Mails:

关键词: charged nanoparticles;    lipids;    osmotic pressure;    dipolar zwitterionic headgroups;    relative permittivity of water;    orientational ordering;   

DOI  :  10.3390/ijms140815312

来源: mdpi

【 摘 要 】

In this work, a theoretical model describing the interaction between a positively or negatively charged nanoparticle and neutral zwitterionic lipid bilayers is presented. It is shown that in the close vicinity of the positively charged nanoparticle, the zwitterionic lipid headgroups are less extended in the direction perpendicular to the membrane surface, while in the vicinity of the negatively charged nanoparticle, the headgroups are more extended. This result coincides with the calculated increase in the osmotic pressure between the zwitterionic lipid surface and positively charged nanoparticle and the decrease of osmotic pressure between the zwitterionic lipid surface and the negatively charged nanoparticle. Our theoretical predictions agree well with the experimentally determined fluidity of a lipid bilayer membrane in contact with positively or negatively charged nanoparticles. The prospective significance of the present work is mainly to contribute to better understanding of the interactions of charged nanoparticles with a zwitterionic lipid bilayer, which may be important in the efficient design of the lipid/nanoparticle nanostructures (like liposomes with encapsulated nanoparticles), which have diverse biomedical applications, including targeted therapy (drug delivery) and imaging of cancer cells.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland