Impaired Pre-mRNA Processing and Altered Architecture of 3' Untranslated Regions Contribute to the Development of Human Disorders

International Journal of Molecular Sciences

Eva Michalova¹  Borivoj Vojtesek¹ 

[1] Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno 656 53, Czech Republic;

关键词: 3′ UTR;    trinucleotide repeat expansion;    polymorphism;    mutation;    cancer;   

DOI  :  10.3390/ijms140815681

来源: mdpi

【 摘 要 】

The biological fate of each mRNA and consequently, the protein to be synthesised, is highly dependent on the nature of the 3′ untranslated region. Despite its non-coding character, the 3′ UTR may affect the final mRNA stability, the localisation, the export from the nucleus and the translation efficiency. The conserved regulatory sequences within 3′ UTRs and the specific elements binding to them enable gene expression control at the posttranscriptional level and all these processes reflect the actual state of the cell including proliferation, differentiation, cellular stress or tumourigenesis. Through this article, we briefly outline how the alterations in the establishment and final architecture of 3′ UTRs may contribute to the development of various disorders in humans.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland