Molecules | |
Inhibitors of Urokinase Type Plasminogen Activator and Cytostatic Activity from Crude Plants Extracts | |
Xueqiang Zha3  Ricardo Diaz3  Jose Javier Rosado Franco3  Veronica Forbes Sanchez3  Ezio Fasoli2  Gabriel Barletta2  Augusto Carvajal1  | |
[1] Department of Biology, University of Puerto Rico at Cayey, 205 Ave. Antonio R. Barcelo, Cayey, PR 00736, USA;Department of Chemistry, University of Puerto Rico at Humacao, CUH Station, Humacao, PR 00792, USA;Department of Chemistry, University of Puerto Rico at Cayey, 205 Ave. Antonio R. Barcelo, Cayey, PR 00736, USA | |
关键词:
urokinase type plasminogen activator (uPA);
uPA inhibitor;
fibrin plate assay;
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DOI : 10.3390/molecules18088945 | |
来源: mdpi | |
【 摘 要 】
In view of the clear evidence that urokinase type plasminogen activator (uPA) plays an important role in the processes of tumor cell metastasis, aortic aneurysm, and multiple sclerosis, it has become a target of choice for pharmacological intervention. The goal of this study was thus to determine the presence of inhibitors of uPA in plants known traditionally for their anti-tumor properties. Crude methanol extracts were prepared from the leaves of plants (14) collected from the subtropical dry forest (Guanica, Puerto Rico), and tested for the presence of inhibitors of uPA using the fibrin plate assay. The extracts that tested positive (6) were then partitioned with petroleum ether, chloroform, ethyl acetate and
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190034292ZK.pdf | 425KB | download |