Principles of miRNA-Target Regulation in Metazoan Models

International Journal of Molecular Sciences

关键词: miR;    miR biogenesis;    miR targets;    miR turnover;    isomiR;    ceRNA;   

DOI  :  10.3390/ijms140816280

来源: mdpi

【 摘 要 】

MicroRNAs (miRs) are key post-transcriptional regulators that silence gene expression by direct base pairing to target sites of RNAs. They have a wide variety of tissue expression patterns and are differentially expressed during development and disease. Their activity and abundance is subject to various levels of control ranging from transcription and biogenesis to miR response elements on RNAs, target cellular levels and miR turnover. This review summarizes and discusses current knowledge on the regulation of miR activity and concludes with novel non-canonical functions that have recently emerged.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland