Molecular Pathways Involved in Colorectal Cancer: Implications for Disease Behavior and Prevention

International Journal of Molecular Sciences

Dora Colussi¹  Giovanni Brandi²  Franco Bazzoli¹ 

[1] Department of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, Pad 5, Bologna 40138, Italy; E-Mails:;Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via Massarenti 9, Pad 5, Bologna 40138, Italy; E-Mail:

关键词: colorectal cancer;    chromosomal instability;    microsatellite instability;    DNA methylation;    aspirin;   

DOI  :  10.3390/ijms140816365

来源: mdpi

【 摘 要 】

Research conducted during the past 30 years has increased our understanding of the mechanisms involved in colorectal cancer initiation and development. The findings have demonstrated the existence of at least three pathways: chromosomal instability, microsatellite instability and CpG island methylator phenotype. Importantly, new studies have shown that inflammation and microRNAs contribute to colorectal carcinogenesis. Recent data have demonstrated that several genetic and epigenetic changes are important in determining patient prognosis and survival. Furthermore, some of these mechanisms are related to patients’ response to drugs, such as aspirin, which could be used for both chemoprevention and treatment in specific settings. Thus, in the near future, we could be able to predict disease behavior based on molecular markers found on tumors, and direct the best treatment options for patients.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland