Influence of Genetic Variations on Levels of Inflammatory Markers of Healthy Subjects at Baseline and One Week after Clopidogrel Therapy; Results of a Preliminary Study

International Journal of Molecular Sciences

Payman Shahabi¹  Gérard Siest¹  Bernard Herbeth¹  Daniel Lambert¹  Christine Masson¹  Jean-Sstien Hulot²  Sstien Bertil³  Pascale Gaussem³ 

[1] UMR INSERM U 1122, IGE-PCV, Faculté de Pharmacie, Université de Lorraine, 30 Rue Lionnois, Nancy 54000, France; E-Mails:;INSERM UMR S956, Université Pierre et Marie Curie, Paris 75005, France; E-Mail:;AP-HP, Hôpital Européen Georges Pompidou, Paris 75908, France; E-Mails:

关键词: inflammation;    cytochrome P450;    polymorphism;    epoxyeicosatrienoic acids;    clopidogrel;    C-reactive protein;    haptoglobin;   

DOI  :  10.3390/ijms140816402

来源: mdpi

【 摘 要 】

We aimed to assess the association between the most common polymorphisms of cytochrome P450 (CYP) epoxygenases on the plasma levels of inflammatory markers in a population of healthy subjects. We also sought to determine whether CYP2C19*2 polymorphism is associated with the anti-inflammatory response to clopidogrel. In a population of 49 healthy young males, the baseline plasma levels of inflammatory markers including C-reactive protein, haptoglobin, orosomucoid acid, CD-40 were compared in carriers vs. non-carriers of the most frequent CYP epoxygenase polymorphisms: CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP2C8*2 and CYP2J2*7. Also, the variation of inflammatory markers from baseline to 7 days after administration of 75 mg per day of clopidogrel were compared in carriers vs. non-carriers of CYP2C19* allele and also in responders vs. hypo-responders to clopidogrel, determined by platelet reactivity tests. There was no significant association between epoxygenase polymorphisms and the baseline levels of inflammatory markers. Likewise, CYP2C19* allele was not associated with anti-inflammatory response to clopidogrel. Our findings did not support the notion that the genetic variations of CYP epoxygenases are associated with the level of inflammatory markers. Moreover, our results did not support the hypothesis that CYP2C19*2 polymorphism is associated with the variability in response to the anti-inflammatory properties of clopidogrel.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland