Immune Regulatory Activity of Vitamin D3 in Head and Neck Cancer

Cancers

M. Rita I. Young¹ 

[1] Research Service, Ralph H. Johnson VA Medical Center, 109 Bee Street, Charleston, SC 29401, USA

关键词: head and neck cancer;    HNSCC;    immune modulation;    immune suppression;    suppressor cells;    vitamin D;   

DOI  :  10.3390/cancers5031072

来源: mdpi

【 摘 要 】

While vitamin D exhibits a multitude of cellular effects that can impact on cancer development and progression, this review focuses on its immune modulatory effects. These immune modulatory effects can be both direct and indirect. Compared to other cancer types, head and neck squamous cell carcinomas (HNSCC) have received less attention, but are a fascination immunologically because of the profound extent to which they inhibit immune defenses. This review describes the mechanisms of some of these immune inhibitory processes and how vitamin D can help overcome aspects of this immune suppression.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.