Untangling the Genetic Basis of Fibrolytic Specialization by Lachnospiraceae and Ruminococcaceae in Diverse Gut Communities

Diversity

Amy Biddle¹  Lucy Stewart¹  Jeffrey Blanchard² 

[1] Department of Microbiology, University of Massachusetts, Amherst, MA 01003, USA; E-Mails:;Department of Biology, University of Massachusetts, Amherst, MA 01003, USA; E-Mail:

关键词: Clostridiales;    Ruminococcaceae;    Lachnospiraceae;    carbohydrate-active enzymes;    comparative genomics;    plant degradation;   

DOI  :  10.3390/d5030627

来源: mdpi

【 摘 要 】

The Lachnospiraceae and Ruminococcaceae are two of the most abundant families from the order Clostridiales found in the mammalian gut environment, and have been associated with the maintenance of gut health. While they are both diverse groups, they share a common role as active plant degraders. By comparing the genomes of the Lachnospiraceae and Ruminococcaceae with the Clostridiaceae, a more commonly free-living group, we identify key carbohydrate-active enzymes, sugar transport mechanisms, and metabolic pathways that distinguish these two commensal groups as specialists for the degradation of complex plant material.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.