Non-Coding RNAs and Cancer

International Journal of Molecular Sciences

Federica Calore¹  Francesca Lovat¹ 

关键词: small non-coding RNAs;    long non-coding RNAs;    cancer;   

DOI  :  10.3390/ijms140817085

来源: mdpi

【 摘 要 】

The discovery of the biological relevance of non-coding RNA (ncRNAs) molecules represents one of the most significant advances in contemporary molecular biology. Expression profiling of human tumors, based on the expression of miRNAs and other short or long ncRNAs, has identified signatures associated with diagnosis, staging, progression, prognosis, and response to treatment. In this review we will discuss the recent remarkable advancement in the understanding the biological functions of human ncRNAs in cancer, the mechanisms of expression and the therapeutic potential.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland