Molecular Interactions in the Development of Brain Metastases

International Journal of Molecular Sciences

Nina Martinez¹  Adrienne Boire¹ 

关键词: CNS metastasis;    metastatic cascade;    vascular co-option;    dormancy;   

DOI  :  10.3390/ijms140817157

来源: mdpi

【 摘 要 】

Brain metastases are a much-feared complication of cancer. The development of brain metastases requires a malignant cell to acquire characteristics that facilitate dissemination away from the primary site, entrance into the nervous system, and establishment in the brain. This review summarizes recent work focused on the molecular derangements leading to brain metastases and outlines areas in need of greater understanding.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland