Environmental Stimuli Shape Biofilm Formation and the Virulence of Periodontal Pathogens

International Journal of Molecular Sciences

Marja T. Pöllänen¹  Annamari Paino² 

[1] Institute of Dentistry, University of Turku, FI-20014 Turku, Finland;Department of Biochemistry and Food Chemistry, University of Turku, FI-20014 Turku, Finland; E-Mails:

关键词: periodontal pathogens;    environmental stimuli;    biofilm EPS;    virulence factors;   

DOI  :  10.3390/ijms140817221

来源: mdpi

【 摘 要 】

Periodontitis is a common inflammatory disease affecting the tooth-supporting structures. It is initiated by bacteria growing as a biofilm at the gingival margin, and communication of the biofilms differs in health and disease. The bacterial composition of periodontitis-associated biofilms has been well documented and is under continual investigation. However, the roles of several host response and inflammation driven environmental stimuli on biofilm formation is not well understood. This review article addresses the effects of environmental factors such as pH, temperature, cytokines, hormones, and oxidative stress on periodontal biofilm formation and bacterial virulence.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland