Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44

Marine Drugs

Chun-Shun Li²  Xiao-Ming Li²  Shu-Shan Gao²  Yan-Hua Lu¹ 

[1] State Key Laboratory of Bioreactor Engineering, East China University of Science & Technology, Shanghai 200237, China; E-Mail:;Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China; E-Mails:

关键词: marine fungus;    sediment;    anthranilic acid;    Penicillium paneum;    cytotoxicity;   

DOI  :  10.3390/md11083068

来源: mdpi

【 摘 要 】

Five new anthranilic acid derivatives, penipacids A–E (1–5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.