The Flux of Phenolic Compounds through Silicone Membranes

Pharmaceutics

John Prybylski¹ 

[1] Department of Medicinal Chemistry, University of Florida, P.O. Box 100485, Gainesville, Florida 32610, USA; E-Mail

关键词: maximum flux;    silicone membrane;    Roberts–Sloan equation;    water solubility;    lipid solubility;    human skin in vitro;   

DOI  :  10.3390/pharmaceutics5030434

来源: mdpi

【 摘 要 】

Phenols as a class of molecules have been reported to exhibit higher log maximum fluxes through human stratum corneum, SC, from water, log J_MHAQ, than other classes of molecules. This suggests that their corresponding log maximum fluxes through silicone from water, log J_MPAQ, may be useful to extend the existing n = 63 log J_MPAQ database to include more log J_MPAQ values greater than 0.0. The log J_MPAQ values for n = 7 phenols predicted to give log J_MPAQ values greater than 0.0 based on their log J_MHAQ values have been experimentally determined. These n = 7 new log J_MPAQ values have been added to the existing n = 63 log J_MPAQ database to give a new n = 70 database and the n = 7 literature log J_MHAQ values have been added to the existing n = 48 log J_MHAQ database (matched to the n = 63 log J_MPAQ database) to give a new n = 55 database. The addition of the n = 7 phenols improved the correlations of these flux databases when fitted to the Roberts-Sloan equation, RS, as well as the correlation between the matched experimental (Exp.) log J_MPAQ with the Exp. log J_MHAQ.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.