2013 Update on Celiac Disease and Eosinophilic Esophagitis

Nutrients

Rinaldo Pellicano¹  Claudio De Angelis¹  Davide Giuseppe Ribaldone¹  Sharmila Fagoonee² 

[1] Department of Gastro-Hepatology, Molinette Hospital, C.so Bramante 88, 10126 Turin, Italy; E-Mails:;Molecular Biotechnology Center, University of Turin, 10126 Turin, Italy; E-Mail:

关键词: celiac disease;    eosinophilic esophagitis;    food allergy;    autoimmune disorders;   

DOI  :  10.3390/nu5093329

来源: mdpi

【 摘 要 】

Celiac disease is a chronic, immune-mediated disorder, characterized by small intestinal inflammation and villous atrophy after the ingestion of gluten by genetically susceptible individuals. Several extraintestinal manifestations have been associated to celiac disease. Eosinophilic esophagitis is a primary disorder of the esophagus characterized by upper gastrointestinal symptoms, absence of gastroesophageal reflux disease and more than 15 eosinophils per high-power field in biopsy specimens. Both celiac disease and eosinophilic esophagitis are caused by aberrant, but distinct, immune responses to ingested antigens and can be responsive to restricted food intake. The aim of this review is to assess whether there is an association between these two pathologies. In the majority of the studies examined, including the studies in pediatric population, the prevalence of eosinophilic esophagitis in subjects with celiac disease was about 10-times that of the general population. We suggest searching for eosinophilic esophagitis in all children undergoing endoscopy for suspicious celiac disease.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.