3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231

Molecules

Nadiah Abu³  M. Nadeem Akhtar¹  Wan Yong Ho²  Swee Keong Yeap⁴ 

[1] Faculty of industrial Sciences & Technology, Universiti Malaysia Pahang, 26300 Lebuhraya Tun Razak, Kuantan Pahang, Malaysia; E-Mail:;The University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia; E-Mail:;Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia, 43400 Serdang, Malaysia; E-Mail:;Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Malaysia; E-Mail:

关键词: anthraquinone;    BHAQ;    cytotoxic;    MDA-MB231;    MCF-7;    migration;   

DOI  :  10.3390/molecules180910367

来源: mdpi

【 摘 要 】

Breast cancer is becoming more prominent in women today. As of now, there are no effective treatments in treating metastatic breast cancer. We have tested the cytotoxic and anti-migration effects of BHAQ, a synthesized anthraquinone, on two breast cancer cell lines, MCF-7 and MDA-MB231. Anthraquinones are an interesting class of molecules that display a wide spectrum of biological applications, including anticancer properties. Cellular inhibition was tested through a MTT assay, double acridine orange/propidium iodide staining and FACS cell cycle analysis. Inhibition of migration was tested by the wound healing method, and migration through a Boyden chamber. BHAQ was cytotoxic towards both cell lines in a dose dependent and possibly cell-dependent manner. Additionally, BHAQ also inhibited the migration of the highly metastatic MDA-MB231 cell line.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.