The Effect of Low-Dose Marine n-3 Fatty Acids on Plasma Levels of sCD36 in Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial

Marine Drugs

Stine Krogh Venø¹  Michael René Skjelbo Nielsen¹  Søren Lundbye-Christensen¹  Erik Berg Schmidt¹ 

[1] Department of Cardiology, Center for Cardiovascular Research, Aalborg University Hospital, Aalborg 9000, Denmark; E-Mails:

关键词: n-3 PUFA;    CD36;    adipose tissue;    cardiovascular disease;    randomised controlled trial;   

DOI  :  10.3390/md11093324

来源: mdpi

【 摘 要 】

CD36 is a scavenger receptor involved in lipid uptake and inflammation. Recently, non-cell-bound CD36 (sCD36) was identified in plasma and suggested to be a marker of lipid accumulation in the vessel wall. Marine n-3 polyunsaturated fatty acids (PUFA) may have cardioprotective effects. This study evaluated the effect of marine n-3 PUFA on sCD36 levels in overweight subjects. Fifty overweight subjects were randomized to 1.1 g of n-3 PUFA or 2 g of olive oil daily for six weeks. Neutrophils were isolated at baseline and after six weeks of treatment while an adipose tissue biopsy was obtained at baseline. The content of n-3 PUFA in adipose tissue and neutrophils was analyzed by gas chromatography, while plasma levels of sCD36 were determined using an enzyme-linked immunosorbent assay (ELISA). After six weeks of supplement plasma sCD36 did not differ between supplements (P = 0.18). There was no significant correlation between plasma sCD36 levels and n-3 PUFA in neutrophils at baseline (r = −0.02, P = 0.88), after six weeks supplement (r = −0.03, P = 0.85) or in adipose tissue (r = 0.14, P = 0.34). This study therefore does not provide evidence for a cardioprotective effect of n-3 PUFA acting through a CD36-dependent mechanism.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.