Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Mesalazine in the Chemoprevention of Colorectal Cancer

International Journal of Molecular Sciences

Carmine Stolfi¹  Veronica De Simone²  Francesco Pallone² 

[1] Department of Systems Medicine, University of Tor Vergata, Via Montpellier 1, Rome 00133, Italy;

关键词: aspirin;    non-steroidal anti-inflammatory drugs;    5-aminosalicylic acid;    cyclooxygenase;    prostaglandins;    colitis-associated colon cancer;    carcinogenesis;    Wnt/β-catenin;    cell cycle;    DNA replication fidelity;   

DOI  :  10.3390/ijms140917972

来源: mdpi

【 摘 要 】

Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide. Although conclusive evidence is still lacking, epidemiologic studies suggest that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) has chemopreventive properties against CRC. Similarly, regular consumption of mesalazine, a drug structurally related to NSAIDs, seems to reduce the risk of CRC in patients with ulcerative colitis. These observations are supported by a large body of experimental data showing the ability of such drugs to inhibit multiple pathways that sustain colon carcinogenesis. This review summarizes the current information on the molecular mechanisms by which NSAIDs and mesalazine could interfere with CRC cell growth and survival.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland