Enzymatic Synthesis and Characterization of Thermosensitive Polyester with Pendent Ketoprofen

Polymers

Wan-Xia Wu²  Hai-Yang Wang²  Na Wang¹  Wei-Wei Zhang²  Han Lai² 

[1] Key Laboratory of Green Chemistry & Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu 610064, China;

关键词: enzymatic synthesis;    CAL-B;    thermosensitive polyester;    ketoprofen;    PEG;   

DOI  :  10.3390/polym5031158

来源: mdpi

【 摘 要 】

Three linear polyesters with pendant ketoprofen were synthesized by copolymerization of polyethylene glycol (PEG) with malic acid (thiomalic acid or aspartic acid) using lipase B acrylic resin from Candida antarctica (CAL-B) at 90 °C respectively. These thermosensitive polyesters exhibit a lower critical solution temperature (LCST) at 10–12 °C. The in vitro study demonstrated that these polyesters could release ketoprofen in neutral and alkaline medium but showed hydrolytic stability in acid medium. These results suggest that, with pendant drugs, these thermosensitive polyesters have potential applications in biomedical materials.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.