EGFR-Ras-Raf Signaling in Epidermal Stem Cells: Roles in Hair Follicle Development, Regeneration, Tissue Remodeling and Epidermal Cancers

International Journal of Molecular Sciences

Eszter Doma¹  Christian Rupp¹ 

关键词: epidermis;    hair follicle;    stem cell;    EGFR signaling;    Ras;    Raf;    SSC;    BCC;    wound healing;   

DOI  :  10.3390/ijms141019361

来源: mdpi

【 摘 要 】

The mammalian skin is the largest organ of the body and its outermost layer, the epidermis, undergoes dynamic lifetime renewal through the activity of somatic stem cell populations. The EGFR-Ras-Raf pathway has a well-described role in skin development and tumor formation. While research mainly focuses on its role in cutaneous tumor initiation and maintenance, much less is known about Ras signaling in the epidermal stem cells, which are the main targets of skin carcinogenesis. In this review, we briefly discuss the properties of the epidermal stem cells and review the role of EGFR-Ras-Raf signaling in keratinocyte stem cells during homeostatic and pathological conditions.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland