Mechanisms of Chemical Carcinogenesis in the Kidneys

International Journal of Molecular Sciences

Robert Radford¹  Helena Frain¹  Michael P. Ryan¹  Craig Slattery¹ 

[1] UCD School of Biomolecular and Biomedical Research, Conway Institute, University College Dublin, Dublin, Dublin 4, Ireland; E-Mails:

关键词: carcinogen;    kidney;    proximal tubule;    mechanism;    bioactivation;   

DOI  :  10.3390/ijms141019416

来源: mdpi

【 摘 要 】

Chemical carcinogens are substances which induce malignant tumours, increase their incidence or decrease the time taken for tumour formation. Often, exposure to chemical carcinogens results in tissue specific patterns of tumorigenicity. The very same anatomical, biochemical and physiological specialisations which permit the kidney to perform its vital roles in maintaining tissue homeostasis may in fact increase the risk of carcinogen exposure and contribute to the organ specific carcinogenicity observed with numerous kidney carcinogens. This review will address the numerous mechanisms which play a role in the concentration, bioactivation, and uptake of substances from both the urine and blood which significantly increase the risk of cancer in the kidney.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland