siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries

Genes

Andrew M. Fukuda¹ 

[1] Department of Physiology, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA; E-Mail:

关键词: brain;    siRNA;    RNAi;    traumatic brain injury;    stroke;    ischemia;    subarachnoid hemorrhage;   

DOI  :  10.3390/genes4030435

来源: mdpi

【 摘 要 】

Ever since the discovery of small interfering ribonucleic acid (siRNA) a little over a decade ago, it has been highly sought after for its potential as a therapeutic agent for many diseases. In this review, we discuss the promising possibility of siRNA to be used as a drug to treat acute brain injuries such as stroke and traumatic brain injury. First, we will give a brief and basic overview of the principle of RNA interference as an effective mechanism to decrease specific protein expression. Then, we will review recent in vivo studies describing siRNA research experiments/treatment options for acute brain diseases. Lastly, we will discuss the future of siRNA as a clinical therapeutic strategy against brain diseases and injuries, while addressing the current obstacles to effective brain delivery.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.