Cytotoxic Constituents from the Stems of Clausena lansium (Lour.) Skeels

Molecules

Hai Yan Jiang⁴  Cheng Fang Wang¹  Li Fan²  Kai Yang¹  Jiang Bin Feng²  Zhu Feng Geng³  Jing Xu⁴  Zhi Wei Deng³  Shu Shan Du¹ 

[1] State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China; E-Mails:;Key Laboratory of Radiological Protection and Nuclear Emergency, Chinese Center for Disease Control and Prevention, Haidian District, Beijing 100875, China; E-Mails:;Analytical and Testing Center, Beijing Normal University, Beijing 100875, China; E-Mails:;College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, Liaoning, China; E-Mails:

关键词: 8-geranyloxypsolaren;    2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde;    Clausena lansium;    carbazoles;    coumarins;    cytotoxic activity;   

DOI  :  10.3390/molecules180910768

来源: mdpi

【 摘 要 】

Six compounds were isolated from the stems of Clausena lansium (Lour.) Skeels by repeated sillica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, 8-geranyloxypsolaren (3) and 2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde (6) were isolated for the first time from this plant. These compounds were screened for cytotoxicity in human cervical cancer (Hela), leukemia (K562), lung cancer (A549), non-small lung carcinoma (H1299) and liver cancer (SMMC-7721). Within the series of cytotoxic tests, compounds 4–6 displayed potent cytotoxic activity against H1299 and SMMC-7721, with the IC₅₀ values of 6.19 to 26.84 μg/mL.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.