Design and Synthesis of N1,N5-bis[4-(5-Alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as Potential Antifungal Prodrugs

Molecules

Nageswara Rao Kode¹  Jean J. Vanden Eynde¹  Annie Mayence¹  Guangdi Wang² 

[1] College of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125, USA; E-Mails:;Department of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USA; E-Mail:

关键词: prodrugs;    amidoximes;    oxadiazoles;    Pneumocystis carinii;    Trypanosoma brucei;   

DOI  :  10.3390/molecules180911250

来源: mdpi

【 摘 要 】

A facile three step synthesis of a group of N¹,N⁵-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides, N¹,N⁵-bis[4-(1,2,4-oxadiazol-3-yl)phenyl]glutaramide and N¹,N⁵-bis[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]glutaramide is described. These products are designed to function as masked bis-amidine prodrugs of a promising N¹,N⁵-bis[4-(N'-(carbamimidoyl)phenyl]glutaramide antifungal lead.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.