Lepidotrichilins A and B, New Protolimonoids with Cytotoxic Activity from Trichilia Lepidota (Meliaceae)

Molecules

Wagner da S. Terra²  Ivo J. C. Vieira²  Raimundo Braz-Filho²  William R. de Freitas¹  Milton M. Kanashiro¹ 

[1] Laboratório de Biologia do Reconhecer, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Avenida Alberto Lamego 2000, 28013-602, Campos dos Goytacazes, Rio de Janeiro, Brazil;Laboratório de Ciências Químicas, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Avenida Alberto Lamego 2000, 28013-602, Campos dos Goytacazes, Rio de Janeiro, Brazil

关键词: Trichilia lepidota;    Meliaceae;    protolimonoids;    spectral data;    leukemic cell lines;   

DOI  :  10.3390/molecules181012180

来源: mdpi

【 摘 要 】

Two novel protolimonoids, named lepidotrichilins A (1) and B (2), four known protolimonoids, 21,23-epoxy-7α-21α-dihydroxyapotirucalla-14,24-dien-3-one (3), 21,23-epoxy-7α-21β-dihydroxyapotiru-calla-14,24-dien-3-one (4), dysorone D (5), deoxy-flindissone (6), and the two steroids β-sitosterol (7) and stigmasterol (8) were identified in leaves of Trichilia lepidota subsp. schumanniana (Harms) T.D. Pennington. From wood the coumarin scopoletin (9) was isolated. The structures were established by NMR (1D ¹H and ¹³C-NMR and 2D ¹H-¹H COSY, HMQC and HMBC), mass spectroscopy and infrared (IR) spectral data. The hexane and methanol extracts of the leaves, the protolimonoids lepidotrichilins A (1) and B (2) (IC₅₀ 42.7 µg mL⁻¹) and the protolimonoid deoxy-flindissone (6; IC₅₀ 9.3 µgmL⁻¹) exhibited significant cytotoxic activity against the MOLT-4 and U937 leukemic cell lines.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.