An Emerging Role for Long Non-Coding RNA Dysregulation in Neurological Disorders

International Journal of Molecular Sciences

Chiara Fenoglio¹  Elisa Ridolfi²  Daniela Galimberti² 

[1] Department of Pathophysiology and Transplantation, University of Milan, “Dino Ferrari” Center, IRCCS Cà Granda Foundation Ospedale Maggiore Policlinico, Via F.Sforza 35, Milan 20122, Italy;

关键词: lncRNA;    RNA;    neurodegenerative diseases;    epigenetics;   

DOI  :  10.3390/ijms141020427

来源: mdpi

【 摘 要 】

A novel class of transcripts, long non coding RNAs (lncRNAs), has recently emerged as key players in several biological processes, including dosage compensation, genomic imprinting, chromatin regulation, embryonic development and segmentation, stem cell pluripotency, cell fate determination and potentially many other biological processes, which still are to be elucidated. LncRNAs are pervasively transcribed in the genome and several lines of evidence correlate dysregulation of different lncRNAs to human diseases including neurological disorders. Although their mechanisms of action are yet to be fully elucidated, evidence suggests lncRNA contributions to the pathogenesis of a number of diseases. In this review, the current state of knowledge linking lncRNAs to different neurological disorders is discussed and potential future directions are considered.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland